Mathematical Sciences Colloquium Series, Leon Glass
Strand Union Building, Procrastinator Theater
Leon Glass, Professor of Physiology and the Isadore Rosenfeld Chair in Cardiology at McGill University, will present "Dynamical Disease: From Theory to the Clinic" as part of MSU's Mathematical Sciences Colloquium Series.
Recent discoveries in genomics and proteomics are revolutionizing our understanding of the mechanisms of disease. Yet, in many diseases the body displays complex abnormal rhythms that are amenable to mathematical analysis. The abnormal rhythms often arise as a consequence of changes in key parameters of an underlying physiological control system, and as such the dynamics give important clues about underlying mechanisms and therapy. Dr. Glass will discuss applications of the concept of dynamical disease to basic research, diagnosis and therapy. He will also describe concrete applications for a variety of different diseases including atrial fibrillation, sudden cardiac death, Parkinsonian tremor, epilepsy and neutropenia. Even though advances in molecular biology will have major impacts in medicine over the long run, for the foreseeable future, physicians will have to deal with the dynamical diseases experienced by their patients.
Dr. Glass is a Fellow of the Royal Society of Canada, the American Physical Society, SIAM and the American Association for the Advancement of Science. He is the recipient of a Guggenheim Fellowship, the Prix Jacques-Rousseau for interdisciplinary research from ACFAS and the Arthur T. Winfree Prize from the Society for Mathematical Biology. Dr. Glass' research focuses on the applications of mathematics to study biological function and rhythms in the cardiovascular system, dynamics and control in genetic and neural networks, and visual perception. He is the coauthor (with Michael Mackey) of From Clocks to Chaos: The Rhythms of Life (Princeton, 1988), which has been translated into Russian, Chinese and Portuguese, and Understanding Nonlinear Dynamics (Springer-Verlag, 1995) with Daniel Kaplan.
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