Department of Microbiology Seminar
Leon Johnson Hall, Room 346
The Spence lab combines pluripotent stem cell and developmental biology with the goal of directing differentiation of pluripotent stem cells into specific endodermal tissue lineages in order to generate novel in vitro human models.
For example, they have developed a novel 3-dimensional system that utilizes human pluripotent stem cells (hPSCs) to generate mature intestinal tissue in culture, called human intestinal organoids (HIOs). Due to their 3-dimensional structure, complex epithelium containing all of the major epithelial cell types and the presence of a crypt-like stem cell domain, HIOs are currently the closest in vitro approximation to the native intestine, allowing unprecedented studies in human intestinal development, homeostasis and disease.
In addition, the Spence lab also studies intestine development and homeostasis using the murine model system and has significant expertise in culturing and manipulating mouse and human enteroids.
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