The Role of Interleukin-2 in Immune Response Regulation
- Thursday, April 9, 2015 from 3:00pm to 4:00pm
- Wilson Hall, 1-144 - view map
The immune system is made up of many adaptive and dynamic components that must be delicately regulated to ensure appropriate, precise, and rapid response to a foreign pathogen. A delayed or inadequate immune response can lead to prolonged disease, while an excessive or under-regulated response can lead to autoimmunity. We are interested in the role cytokines, in particular Interleukin-2 (IL-2), play in maintaining this balance. Through the use of several deterministic models, we try to understand how IL-2 signaling might play a role in T cell dierentiation as well as in maintaining the balance between under-response and autoimmunity. Additionally, we will look at how Daclizumab, a monoclonal antibody against one component of the IL-2 receptor, might aect this equilibrium. We will also briey review our work on the CRISPR system, channeling in metabolic pathways, and the design of a multiple sclerosis diagnostic/progression tool.
- Department of Mathematical Sciences