Kopriva Science Seminar Series, Amanda Byer
- Thursday, October 12, 2017 at 3:10pm
- Chemistry & Biochemistry Building, Byker Auditorium - view map
Amanda Byer, a doctoral student in the Department of Chemistry and Biochemistry and recipient of a Kopriva Graduate Student Fellowship, will present "Radical SAM Enzyme Mechanism Investigations" as part of the College of Letters and Sciences's Kopriva Science Seminar Series.
Radical SAM (S-adenosyl-L-methionine) enzymes constitute one of the largest enzyme superfamilies with ~114,000 members from all domains of life. When human radical SAM enzymes fail, disease states can ensue, including increased susceptibility to viral infection, diabetes mellitus, impaired cardiac and respiratory function, congenital heart disease, retrovirus infection and cofactor deficiencies. During catalysis, all radical SAM enzymes generate a highly reactive species, the 5’-deoxyadenosyl (dAdo) radical. However, despite its reactivity, the dAdo radical does not initiate damaging uncontrolled radical proliferation. We hypothesize that the enzyme environment constrains this radical reactivity while an iron-sulfur cluster and dAdo comprise an organometallic key intermediate. Employing various spectroscopic techniques, Byer's research investigates chemical intermediates in these radical SAM enzymes to determine how these fascinating organometallic biochemical systems function.
A reception will follow the lecture.
Byer's lecture is presented by the Kopriva Science Seminar Series, which is funded through an endowment created by Phil Kopriva, a 1957 microbiology graduate from MSU. Kopriva, who died in 2002, also created an endowment to fund the Kopriva Graduate Fellowship Program, which provides support and opportunities for graduate students in the College of Letters and Science, particularly in the biomedical sciences. The series features seminars by MSU graduate students, faculty members and guest speakers. For more information about this and other Kopriva lectures, please visit www.montana.edu/lettersandscience/kopriva.html.