Activity-dependent Transmitter Under the Acute Sympathetic Stress Response
- Wednesday, September 6, 2017 at 3:10pm
- Plant Biosciences Building, 108 - view map
Dr. Corey Smith from the Department of Physiology and Biophysics at Case Western Reserve University will present "Activity-dependent Transmitter Under the Acute Sympathetic Stress Response", Wednesday, September 6th at 3:10 p.m. in 108 Plant Bioscience Building.
Synopsis: Neuroendocrine chromaffin cells of the adrenal medulla are a primary output of the sympathetic nervous system and secrete a host of transmitter molecules, including catecholamines and neuropeptides, through the fusion of dense core secretory granules. At basal firing rates, set by the symapthetic tone, secreted catecholamines regulate homeostatic processes such as enteric function, vascular tone and insulin secretion. Stress leads to elevated catecholamine secretion, increasing cardiac output and glucagon levels. Stress also evokes neuro- and vaso-active peptide transmitter release, which regulate cardiac output, vasoconstriction, neuronal activity and overall metabolism. Our long-term goal is to understand how the sympathetic nervous system coordinates differential transmitter output from the adrenal medulla and how chromaffin cells separately regulate the release of co-packaged catecholamine and neuropeptides under basal-firing and stress activation.
Corey Smith, PhD
Case Western Reserve University
School of Medicine E510
10900 Euclid Ave
Cleveland, OH 44106-4970
- Lisa Musgrave