Department of Chemistry and Biochemistry Seminar
- Friday, November 3, 2017 from 3:10pm to 4:00pm
- Chemistry and Biochemistry Building, Byker Auditorium - view map
Dr. Steve Patterson (The University of Minnesota) will present a research seminar titled "Sulfanegen: Discovery and Development of a Novel Cyanide Antidote."
Cyanide is a well-known archetypal poison that has been used for centuries. It inhibits cytrochrome c oxidase, inhibiting aerobic cellular respiration i.e. the utilization of oxygen to form ATP. The consequences of acute cyanide exposure are severe: exposure results in loss of consciousness, cardiac and respiratory failure, hypoxic brain injury, and for high dose exposure (>10 mg/kg NaCN) death can occur in minutes. In a mass-casualty scenario, such as an industrial accident or terrorist attack, currently available cyanide antidotes would leave many victims untreated in the short time available for successful administration of a medical countermeasure. This restricted therapeutic window reflects the rate-limiting step of intravenous administration, which is relatively slow and requires well-trained medical personnel. Therefore, there is a need for a rapidly acting antidote that is suitable for rapid administration to large numbers of people. To meet this need, our laboratory is developing sulfanegen, a potential antidote for cyanide poisoning with a novel mechanism based on the enzyme 3-mercaptopyruvate sulfurtransferase (3-MST). The use of sulfanegen in experimental models of cyanide exposure results in detoxification via conversion of cyanide to thiocyanate. Additionally, sulfanegen can be rapidly administered by intramuscular injection and has demonstrated efficacy in commonly used laboratory models of humans. The discussion will summarize the journey from concept to clinical leads for this promising cyanide antidote.
- Department of Chemistry and Biochemistry