- Friday, March 2, 2018 from 1:10pm to 2:00pm
- Plant Biosciences Building, 108 - view map
Dr. Brian J. Mitchell, associate professor at Northwestern University Feinberg School of Medicine, will speak on the development and polarization of ciliated epithelia. The directed beating of motile cilia is a critical aspect of tissue function in a variety of developmental and physiological contexts including proper neural development, egg migration through the oviduct, and mucus clearance in the respiratory tract. The loss of cilia driven flow results in a wide range of phenotypes including hydrocephaly, infertility, situs inversus, and respiratory dysfunction. We use the ciliated epithelium of Xenopus larval skin as a model system to address multiple questions about the development of this tissue. In particular, this talk will focus on the polarization of ciliated epithelia. Most epithelial cell polarize along the axis of the tissue, a feature known as planar cell polarity (PCP). The initiation of PCP requires cell-cell signaling via the non-canonical Wnt/PCP pathway. Additionally, changes in the cytoskeleton both facilitate and reflect this polarity. The mechanicistic link between PCP signaling and changes to the cytoskeleton remain largely obscure, however, we have itdentified a novel microtubule regulating protein CLAMP that has a profound role in the establishment of proper polarity in ciliated epithelia.