Dr. Masafumi Yoshinaga to give TBI seminar- Arsenic-based Antibiotics and the Resistance Mechanisms
- Monday, April 23, 2018 from 3:10pm to 4:00pm
- Plant Biosciences Building, 108 - view map
Arsenic, the most pervasive environmental toxin, has exerted selective pressures on organisms since life emergence on Earth, resulting in evolution of arsenic resistance mechanisms in nearly every existing organism. Some have flexibly adopted even to utilize the toxin, represented by bacterial arsenate respiration. The current talk will present a novel example of arsenic utilizations – arsenic-based antibiotics. My recent results strongly suggest that degradation of environmental organoarsenicals is the result of competition for survival among bacteria: some microbes activate benign organoarsenicals and utilize them as antibiotics to kill off competitors, whereas other members of the community detoxify activated organoarsenicals as antibiotic resistance mechanisms. The presentation will also describe about arsinothricin, the newly discovered arsenic-containing antibiotic and its resistance mechanism.
- Christine Smith